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Margarida D Amaral Selected Research

Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)

3/2022Pediatric population with cystic fibrosis in the centre of Portugal: candidates for new therapies.
2/2022CFTR, Cell Junctions and the Cytoskeleton.
10/2021Cross-talk of inflammatory mediators and airway epithelium reveals the cystic fibrosis transmembrane conductance regulator as a major target.
1/2021Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis.
10/2020Mutant CFTR Drives TWIST1 mediated epithelial-mesenchymal transition.
4/2020What Role Does CFTR Play in Development, Differentiation, Regeneration and Cancer?
1/2020KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway.
1/2020Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation.
1/2020CFTR processing, trafficking and interactions.
1/2019CFTR modulator theratyping: Current status, gaps and future directions.
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Margarida D Amaral Research Topics

Disease

76Cystic Fibrosis (Mucoviscidosis)
03/2022 - 09/2002
8Inborn Genetic Diseases (Disease, Hereditary)
01/2019 - 01/2005
7Lung Diseases (Lung Disease)
09/2020 - 11/2002
5Neoplasms (Cancer)
01/2022 - 07/2007
3Inflammation (Inflammations)
10/2021 - 04/2006
3Fibrosis (Cirrhosis)
10/2020 - 11/2006
2Disease Progression
01/2021 - 11/2015
1Dehydration (Water Stress)
02/2022
1Rare Diseases (Rare Disease)
01/2022
1Necrosis
10/2021
1Infections
01/2016
1Respiratory Tract Diseases (Respiratory Tract Disease)
01/2015
1Pain (Aches)
05/2013
1Autosomal Dominant Polycystic Kidney (ADPKD)
10/2012
1Cysts
10/2012
1Channelopathies
07/2007
1Cardiovascular Diseases (Cardiovascular Disease)
07/2007
1Adenocarcinoma
01/2005

Drug/Important Bio-Agent (IBA)

29Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
03/2022 - 09/2002
16Proteins (Proteins, Gene)FDA Link
01/2022 - 11/2003
9Chloride Channels (Chloride Channel)IBA
03/2022 - 09/2002
7ChloridesIBA
02/2022 - 09/2003
7AnionsIBA
01/2022 - 10/2004
6Biomarkers (Surrogate Marker)IBA
09/2020 - 08/2004
5Pharmaceutical PreparationsIBA
01/2022 - 01/2013
5Messenger RNA (mRNA)IBA
11/2021 - 11/2002
3Bicarbonates (Hydrogen Carbonate)IBA
02/2022 - 01/2021
3ivacaftorIBA
01/2021 - 01/2015
3ColforsinIBA
12/2020 - 10/2012
3Adenosine Triphosphate (ATP)IBA
06/2020 - 01/2013
3Phenylalanine (L-Phenylalanine)FDA Link
01/2013 - 04/2006
3NucleotidesIBA
12/2009 - 11/2003
2Ion Channels (Ion Channel)IBA
02/2022 - 01/2021
2Small Interfering RNA (siRNA)IBA
01/2022 - 09/2013
2lumacaftorIBA
05/2015 - 01/2015
2CalciumIBA
03/2013 - 11/2011
2Membrane Proteins (Integral Membrane Proteins)IBA
07/2007 - 09/2002
1SodiumIBA
02/2022
1Interleukin-8 (Interleukin 8)IBA
10/2021
1Interleukin-10 (Interleukin 10)IBA
10/2021
1Interleukin-4 (Interleukin 4)IBA
10/2021
1Interleukin-17 (Interleukin 17)IBA
10/2021
1CytokinesIBA
10/2021
1Interleukin-22 (IL-22)IBA
10/2021
1Anoctamin-1IBA
10/2021
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
06/2020
1Nonsense Codon (Nonsense Mutation)IBA
01/2019
1Phosphatidylinositols (Phosphatidylinositol)IBA
01/2018
1Therapeutic UsesIBA
01/2018
1Antisense OligonucleotidesIBA
02/2016
1IodidesIBA
08/2015
1Investigational DrugsIBA
01/2015
1RNA (Ribonucleic Acid)IBA
10/2014
1SaltsIBA
09/2013
1Epithelial Sodium ChannelsIBA
09/2013
1Estrogens (Estrogen)FDA Link
03/2013
1INO-4995IBA
01/2013
1CollagenIBA
10/2012
1GelsIBA
10/2012
1VRT 532IBA
10/2012
14- cyclohexyloxy- 2- (1- (4- (4- methoxy- benzenesulfonyl)piperazin- 1- yl)ethyl)quinazolineIBA
10/2012
1Molecular Chaperones (Chaperone, Molecular)IBA
01/2012
1Casein Kinases (Casein Kinase)IBA
11/2011
1Phosphotransferases (Kinase)IBA
11/2011
11-ethyl-2-benzimidazolinoneIBA
01/2011
1FlavonoidsIBA
01/2007
1ElectrolytesIBA
01/2007
1Arginine (L-Arginine)FDA Link
11/2006
1CalnexinIBA
06/2005
1DNA (Deoxyribonucleic Acid)IBA
08/2004

Therapy/Procedure

13Therapeutics
03/2022 - 08/2004
3Precision Medicine
01/2022 - 11/2015
1Drug Therapy (Chemotherapy)
10/2020
1Surgical Instruments (Clip)
05/2013